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General description	Non-essential amino acid from urea cycle with vasodilatating effect.
Found	- watermellon - legumes - nuts
Anti-aging role	- prevent cardiovascular diseases - improve circulation - improve sport performances - reduce fatigue - improve endurance (both aerobic and anaerobic sports) - prevents muscle pain after intensive workout - enhance nitric oxide, arginine, ornithine and creatine level - lower blood pressure - reduce erectile dysfunction symptoms - it's considered that may improve intestinal damage, Parkinson and coeliac desease symptoms
Deficiency symptoms	Not possible.
Therapeutic doses	- erectile dysfunction: 1000 mg 3 times a day - circulation: 1800 mg citrulline malate in one dose - sport performances: 6000 - 8000 mg citrulline malate one hour before workout
Maximum safe level	15 mg/day
Side effects	Not recorded.
Contraindications	- pregnancy, lactating
Interactions	- medications for treating erectile dysfunction - nitrates - medications for treating blood pressure
Composition formulas	- usually in form of citrulline malate, by itself or in combination with arginine and/or ornithine
Other remarks	- in kidney citrulline breaks into arginine and nitric oxide - citrulline supplementation causes ornithine and arginine increase

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